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This article reviews diagnosis of cerebral amyloid angiopathy(CAA)during life and possible approaches to prevention.A clinical diagnosis of" probable CAA"can be made in patients aged 60 years or older with multiple hemorrhages confined to lobar brain regions and no other cause of hemorrhage.Gradient-echo MRI facilitates diagnosis by showing previous hemorrhages with high sensitivity.This technique can also mark the progression of CAA,as 50%of studied patients developed new petechial hemorrhages during 1.5 years of follow-up.The apolipoprotein E e2 and e4 alleles are associated with increased risk and earlier age of first hemorrhage,but are neither sensitive nor specific for CAA.The major remaining challenges are to develop new markers for the presence of CAA and treatment to block vascular amyloid deposition and vessel breakdown. |
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amyloid angiopathy,cerebral
anticoagulant,complications of
anticoagulant,contraindications
anticoagulant,treatment
apolipoprotein E
atrial fibrillation
cerebrovascular accident,prevention of
intracerebral hemorrhage
intracerebral hemorrhage,lobar
intracerebral hemorrhage,multiple
intracerebral hemorrhage,recurrent
MRI
MRI,abnormal
MRI,gradient-echo
MRI,serial
neurologic disease,diagnoses of
old age,neurology of
prevention of neurologic disorders
review article
risk factors
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